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The Institute of Environmental Toxicology

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By: Sean Moloughney

Editor, Nutraceuticals World

The Institute of Environmental Toxicology, Ibaraki, Japan, has performed several toxicology studies on CoQ10, a product of ZMC The Woodlands, TX, and confirmed the product’s safety at high doses. Tests performed were acute oral toxicity, repeated dose 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, as well as a 4-week immunotoxicity study. The tests confirmed the oral LD50 is greater than 2000 mg/kg, there was no oral toxicity in rats receiving 1000 mg/kg/day for 4 weeks, is not mutagenic to the bacteria used, did not induce either structural or numerical chromosome aberrations, did not induce micronuclei in bone marrow cells of mice, had no skin sensitizing potential in the guinea pig maximization test, and had no toxic effects on immuno-toxicological parameters tested at 1000 mg/kg body weight/day for 4 weeks.

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